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Mitochondrial DNA alterations in the domestic dog (Canis lupus familiaris) and their association with development of diseases: A review.

Mitochondrion - 1 Mar 2022

Tkaczyk-Wlizło Angelika, Kowal Krzysztof, Ślaska Brygida

Abstract excerpt

Currently, the issue of the aetiology of mitochondrial diseases resulting from mitochondrial DNA (mtDNA) defects is underestimated. Genetic research is mostly focused on alterations in the nuclear genome (nDNA), and its impact on disease development as well as further health consequences without considering mtDNA abnormalities. However, in the case of energy-dependent diseases, it is important to understand the...

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PMID: 35134592
DOI: 10.1016/j.mito.2022.02.001

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