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Mutations of Key Functional Residues in CRM1/XPO1 Differently Alter Its Intranuclear Localization and the Nuclear Export of Endogenous Cargos.

Biomolecules - 10 Dec 2024

Omaetxebarria Miren Josu, Sendino Maria, Arrizabalaga Liher, Mota Irune, Zubiaga Ana Maria, Rodríguez José Antonio

Abstract excerpt

CRM1 (XPO1) has been well-characterized as a shuttling receptor that mediates the export of protein and RNA cargos to the cytoplasm, and previous analyses have pinpointed several key residues (A541, F572, K568, S1055, and Q742) that modulate CRM1 export activity. CRM1 also has a less studied nuclear function in RNA biogenesis, which is reflected by its localization to the Cajal body and the nucleolus. Here, we...

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Identifiers

PMID: 39766285
DOI: 10.3390/biom14121578
PMCID: PMC11674046

Genes

XPO1

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