Article

Causally-anchored multi-omic deep learning recovers exercise-responsive and ageing-causal genes from human physical activity

2026-01-05

Abstract excerpt

Physical activity is among the most robust epidemiological correlates of reduced mortality and multi-morbidity, yet the molecular mechanisms through which exercise exerts these effects in humans remain incompletely resolved. This study combines causally-anchored multi-omic Mendelian Randomisation (MR) with graph-based deep learning for gene prioritisation in human exercise-ageing biology, using accelerometer-deriv...

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Literature Corpus work: 0e90e652-eb41-5b8e-b3bb-1eece13a47cf
DOI: 10.64898/2025.12.26.25343061

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