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Article

Genetic associations with lipoprotein subfractions provide information on their biological nature.

Human molecular genetics - 15 Mar 2012

Petersen Ann-Kristin, Stark Klaus, Musameh Muntaser D, Nelson Christopher P, Römisch-Margl Werner, Kremer Werner, Raffler Johannes, Krug Susanne, Skurk Thomas, Rist Manuela J, Daniel Hannelore, Hauner Hans, Adamski Jerzy, Tomaszewski Maciej, Döring Angela, Peters Annette, Wichmann H-Erich, Kaess Bernhard M, Kalbitzer Hans Robert, Huber Fritz, Pfahlert Volker, Samani Nilesh J, Kronenberg Florian, Dieplinger Hans, Illig Thomas, Hengstenberg Christian, Suhre Karsten, Gieger Christian, Kastenmüller Gabi

Abstract excerpt

Adverse levels of lipoproteins are highly heritable and constitute risk factors for cardiovascular outcomes. Hitherto, genome-wide association studies revealed 95 lipid-associated loci. However, due to the small effect sizes of these associations large sample numbers (>100 000 samples) were needed. Here we show that analyzing more refined lipid phenotypes, namely lipoprotein subfractions, can increase the number...

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Identifiers

PMID: 22156577
DOI: 10.1093/hmg/ddr580

Genes

APOA1
CETP
GCKR
LIPC
SORT1
APOB
FADS1
PLTP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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