Ensemble learning-based predictor for driver synonymous mutation with sequence representation.

Abstract excerpt

Synonymous mutations, once considered neutral, are now understood to have significant implications for a variety of diseases, particularly cancer. It is indispensable to identify these driver synonymous mutations in human cancers, yet current methods are constrained by data limitations. In this study, we initially investigate the impact of sequence-based features, including DNA shape, physicochemical properties...

Topics

• Humans
• Algorithms
• Computational Biology
• Deep Learning
• DNA
• Ensemble Learning
• Mutation