Article
Prediction of disease causing non-synonymous SNPs by the Artificial Neural Network Predictor NetDiseaseSNP.
PloS one - 1 Jan 2013
Johansen Morten Bo, Izarzugaza Jose M G, Brunak Søren, Petersen Thomas Nordahl, Gupta Ramneek
Abstract excerpt
We have developed a sequence conservation-based artificial neural network predictor called NetDiseaseSNP which classifies nsSNPs as disease-causing or neutral. Our method uses the excellent alignment generation algorithm of SIFT to identify related sequences and a combination of 31 features assessing sequence conservation and the predicted surface accessibility to produce a single score which can be used to rank...
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