Article
SARS-CoV-2 mouse adaptation selects virulence mutations that cause TNF-driven age-dependent severe disease with human correlates.
Proceedings of the National Academy of Sciences of the United States of America - 8 Aug 2023
Bader Stefanie M, Cooney James P, Sheerin Dylan, Taiaroa George, Harty Leigh, Davidson Kathryn C, Mackiewicz Liana, Dayton Merle, Wilcox Stephen, Whitehead Lachlan, Rogers Kelly L, Georgy Smitha Rose, Coussens Anna K, Grimley Samantha L, Corbin Vincent, Pitt Miranda, Coin Lachlan, Pickering Raelene, Thomas Merlin, Allison Cody C, McAuley Julie, Purcell Damian F J, Doerflinger Marcel, Pellegrini Marc
Abstract excerpt
The diversity of COVID-19 disease in otherwise healthy people, from seemingly asymptomatic infection to severe life-threatening disease, is not clearly understood. We passaged a naturally occurring near-ancestral SARS-CoV-2 variant, capable of infecting wild-type mice, and identified viral genomic mutations coinciding with the acquisition of severe disease in young adult mice and lethality in aged animals....
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