Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Discovery of a cardiolipin synthase utilizing phosphatidylethanolamine and phosphatidylglycerol as substrates.

Proceedings of the National Academy of Sciences of the United States of America - 9 Oct 2012

Tan Brandon K, Bogdanov Mikhail, Zhao Jinshi, Dowhan William, Raetz Christian R H, Guan Ziqiang

Abstract excerpt

Depending on growth phase and culture conditions, cardiolipin (CL) makes up 5-15% of the phospholipids in Escherichia coli with the remainder being primarily phosphatidylethanolamine (PE) and phosphatidylglycerol (PG). In E. coli, the cls and ybhO genes (renamed clsA and clsB, respectively) each encode a CL synthase (Cls) that catalyzes the condensation of two PG molecules to form CL and glycerol. However, a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cardiolipins
Share to Chromatography, Liquid

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Isoenzymes

Share to Phosphatidylethanolamines

Share to Phosphatidylglycerols

Share to Substrate Specificity

Share to Tandem Mass Spectrometry

Share to Transferases (Other Substituted Phosphate Groups)

Source

Open in PubMed Open full text

Identifiers

PMID: 22988102
DOI: 10.1073/pnas.1212797109
PMCID: PMC3478633

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Discovery of a cardiolipin synthase utilizing phosphatidylethanolamine and phosphatidylglycerol as substrates.PMID 22988102Read ↗

Active increase in cardiolipin synthesis in the stationary growth phase and its physiological significance in Escherichia coli.Semantic proximity Read ↗

Characterization of Staphylococcus aureus cardiolipin synthases 1 and 2 and their contribution to accumulation of cardiolipin in stationary phase and within phagocytes.Semantic proximity Read ↗

Essential Role of LapD in the Absence of Cardiolipins.Semantic proximity Read ↗

Regulation of Bacterial Two-Component Systems by CardiolipinSemantic proximity Read ↗

Two Distinct Cardiolipin Synthases Operate in Agrobacterium tumefaciens.Semantic proximity Read ↗

Cardiolipin synthase is required for Streptomyces coelicolor morphogenesis.Semantic proximity Read ↗

Cardiolipin is required in vivo for the stability of bacterial translocon and optimal membrane protein translocation and insertion.Semantic proximity Read ↗

Inhibition of cardiolipin biosynthesis partially suppresses the sensitivity of an Escherichia coli mutant lacking OmpC to envelope stress.Semantic proximity Read ↗

Biosynthesis and function of phospholipids in Escherichia coli.Semantic proximity Read ↗

Its own architect: Flipping cardiolipin synthase.Semantic proximity Read ↗

Crystallization and preliminary X-ray diffraction analysis of YejM from Salmonella typhimurium: an essential inner membrane protein involved in outer membrane directed cardiolipin transportSemantic proximity Read ↗

A Novel Lysophosphatidic Acid Acyltransferase of Escherichia coli Produces Membrane Phospholipids with a cis-vaccenoyl Group and Is Related to Flagellar Formation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.