Article
Substrate Selectivity of Lysophospholipid Transporter LplT Involved in Membrane Phospholipid Remodeling in Escherichia coli.
The Journal of biological chemistry - 29 Jan 2016
Lin Yibin, Bogdanov Mikhail, Tong Shuilong, Guan Ziqiang, Zheng Lei
Abstract excerpt
Lysophospholipid transporter (LplT) was previously found to be primarily involved in 2-acyl lysophosphatidylethanolamine (lyso-PE) recycling in Gram-negative bacteria. This work identifies the potent role of LplT in maintaining membrane stability and integrity in the Escherichia coli envelope. Here we demonstrate the involvement of LplT in the recycling of three major bacterial phospholipids using a combination...
Topics
- Binding Sites
- Binding, Competitive
- Cardiolipins
- Cell Membrane
- Escherichia coli
- Escherichia coli Proteins
- Gene Deletion
- Hydrolysis
- Klebsiella pneumoniae
- Lysophospholipids
- Mass Spectrometry
- Microscopy, Fluorescence
- Models, Molecular