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Article

A metabolic interplay coordinated by HLX regulates myeloid differentiation and AML through partly overlapping pathways.

Nature communications - 6 Aug 2018

Piragyte Indre, Clapes Thomas, Polyzou Aikaterini, Klein Geltink Ramon I, Lefkopoulos Stylianos, Yin Na, Cauchy Pierre, Curtis Jonathan D, Klaeylé Lhéanna, Langa Xavier, Beckmann Cora C A, Wlodarski Marcin W, Müller Patrick, Van Essen Dominic, Rambold Angelika, Kapp Friedrich G, Mione Marina, Buescher Joerg M, Pearce Erika L, Polyzos Alexander, Trompouki Eirini

Abstract excerpt

The H2.0-like homeobox transcription factor (HLX) regulates hematopoietic differentiation and is overexpressed in Acute Myeloid Leukemia (AML), but the mechanisms underlying these functions remain unclear. We demonstrate here that HLX overexpression leads to a myeloid differentiation block both in zebrafish and human hematopoietic stem and progenitor cells (HSPCs). We show that HLX overexpression leads to...

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Identifiers

PMID: 30082823
DOI: 10.1038/s41467-018-05311-4
PMCID: PMC6078963

Genes

HLX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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