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Article

A Fluorescence-Enhanced Probe Enables Rapid Detection of BRAF(V600E) Mutant Activity in Living Cells and Tumor Tissues.

Analytical chemistry - 1 Sept 2026

Lei Qian, Qi Chang, Xiao Zhaolin, Song Chao, Tian Panwen, Wu Mingyu, Deng Hui

Abstract excerpt

BRAF is the most frequently mutated protein kinase in human cancers, and in particular, the V600E mutation in the kinase domain confers a constitutively active conformation on the protein, thereby promoting oncogenesis. To date, several BRAF kinase inhibitors have been approved for treating cancer patients with the BRAF(V600E) mutation. However, the benefits of BRAF kinase inhibitors in clinical practice are...

Read the complete abstract on PubMed

Topics

Proto-Oncogene Proteins B-raf
Humans
Animals
Fluorescent Dyes
Mice
Mutation
Cell Line, Tumor

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Fluorescent Chemosensor Compounds

Mice, Nude

Protein Kinase Inhibitors

Lung Neoplasms

Source

Identifiers

PMID: 42689560
DOI: 10.1021/acs.analchem.6c03277

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 25 Oct 2026.

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