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Article

A single mutation in dairy cow-associated H5N1 viruses increases receptor binding breadth.

Nature communications - 30 Dec 2024

Good Marina R, Fernández-Quintero Monica L, Ji Wei, Rodriguez Alesandra J, Han Julianna, Ward Andrew B, Guthmiller Jenna J

Abstract excerpt

Clade 2.3.4.4b H5N1 is causing an unprecedented outbreak in dairy cows in the United States. To understand if recent H5N1 viruses are changing their receptor use, we screened recombinant hemagglutinin (HA) from historical and recent 2.3.4.4b H5N1 viruses for binding to distinct glycans bearing terminal sialic acids using a glycan microarray. We find that H5 from A/Texas/37/2024, an isolate from the dairy cow...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hemagglutinin Glycoproteins, Influenza Virus

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Identifiers

PMID: 39737954
DOI: 10.1038/s41467-024-54934-3
PMCID: PMC11685663

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