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A RAD51 assay feasible in routine tumor samples calls PARP inhibitor response beyond BRCA mutation

30 Oct 2018

Abstract excerpt

Poly(ADP‐ribose) polymerase (PARP) inhibitors (PARPi) are effective in cancers with defective homologous recombination DNA repair (HRR), including BRCA1/2‐related cancers. A test to identify additional HRR‐deficient tumors will help to extend their use in new indications. We evaluated the activity of the PARPi olaparib in patient‐derived tumor xenografts (PDXs) from breast cancer (BC) patients and investigated...

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PMID: 30377213
DOI: 10.15252/emmm.201809172

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