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Article

HIV-1 exploits LBPA-dependent intraepithelial trafficking for productive infection of human intestinal mucosa

27 Dec 2024

Abstract excerpt

The gastrointestinal tract is a prominent portal of entry for HIV-1 during sexual or perinatal transmission, as well as a major site of HIV-1 persistence and replication. Elucidation of underlying mechanisms of intestinal HIV-1 infection are thus needed for the advancement of HIV-1 curative therapies. Here, we present a human 2D intestinal immuno-organoid system to model HIV-1 disease that recapitulates tissue...

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PMID: 39729509
DOI: 10.1371/journal.ppat.1012714

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