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Article

The Achilles Heel of the Trojan Horse Model of HIV-1 trans-Infection

26 Jun 2008

Abstract excerpt

To ensure their survival, microbial pathogens have evolved diverse strategies to subvert host immune defenses. The human retrovirus HIV-1 has been proposed to hijack the natural endocytic function of dendritic cells (DCs) to infect interacting CD4 T cells in a process termed trans-infection. Although DCs can be directly infected by certain strains of HIV-1, productive infection of DCs is not required during...

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PMID: 18584030
DOI: 10.1371/journal.ppat.1000051

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