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Clinical Molecular Testing for Clonal Relatedness of Second Melanoma Tumors: A Real-World Appraisal.

Archives of pathology & laboratory medicine - 1 Sept 2025

Plotzke Jaclyn M, Manthei David, Fullen Douglas R, Chan May P, Bresler Scott C, Xiao Hong, Andea Aleodor A, Harms Paul W

Abstract excerpt

CONTEXT.—: Patients with melanoma can develop second tumors representing either metastases or new primary melanoma. This distinction has profound implications for management. Although clinicopathologic features are often sufficient, molecular assays can support the presence or absence of clonal relatedness in challenging cases. However, the potential for false-positive and false-negative results in this context...

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PMID: 39722598
DOI: 10.5858/arpa.2024-0267-OA

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