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Article

A novel GIT2-BRAF fusion in pilocytic astrocytoma.

Diagnostic pathology - 15 Nov 2017

Helgager Jeffrey, Lidov Hart G, Mahadevan Navin R, Kieran Mark W, Ligon Keith L, Alexandrescu Sanda

Abstract excerpt

BACKGROUND: KIAA1549-BRAF fusion is the most common genetic event in pilocytic astrocytoma (PA), and leads to activation of the mitogen activated protein kinase (MAPK) signaling pathway. Fusions of BRAF with other partner genes, as well as other genetic alterations not involving BRAF but also leading to MAPK pathway activation have been described rarely. CASE PRESENTATION: We present a new fusion partner in the...

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Share to Astrocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Oncogene Proteins, Fusion

Share to Proto-Oncogene Proteins B-raf

Source

Open in PubMed Open full text

Identifiers

PMID: 29141672
DOI: 10.1186/s13000-017-0669-5
PMCID: PMC5688665

Genes

BRAF
GIT2
GFAP
IDH1
OLIG2
SOX2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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