Article
Examination of MGMT as a risk gene for dementia in the Amish.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Jan 2025
Main Leighanne R, Song Yeunjoo E, Lynn Audrey, Laux Renee A, Miskimen Kristy L, Osterman Michael D, Cuccaro Michael L, Ogrocki Paula K, Lerner Alan J, Vance Jeffery M, Fuzzell M Denise, Fuzzell Sarada L, Hochstetler Sherri D, Dorfsman Daniel A, Caywood Laura J, Prough Michael B, Adams Larry D, Clouse Jason E, Herington Sharlene D, Scott William K, Pericak-Vance Margaret A, Haines Jonathan L
Abstract excerpt
INTRODUCTION: Recently, the O-6-methylguanine-DNA methyltransferase (MGMT) locus was proposed as influencing the risk of Alzheimer's disease (AD) in women who did not carry the apolipoprotein E ε4 allele. We examined an Amish founder population for any influence of genetic variation in and around the MGMT locus on the risk for dementia. METHODS: Genetic association was performed for single nucleotide...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.