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Article

Angiogenic switching in cerebral cavernous malformations driven by MAP3K3-PIK3CA synergy.

Brain : a journal of neurology - 3 Aug 2026

Ren Jian, Ren Yeqing, Tian An, Cui Ziwei, Wang Daochao, Yu Hao, Jiang Chendan, Yu Jiaxing, Zhang Shikun, Chen Jing, Liang Shuang, Gu Yu, Wang Yiqing, Lei Jianfeng, Zheng Xiangjian, Xing Dong, Zhang Hongqi, Hong Tao

Abstract excerpt

Cerebral cavernous malformations are common vascular anomalies in the CNS that predispose individuals to seizures and haemorrhagic stroke. Familial forms are linked to germline loss-of-function mutations in CCM1-3, and sporadic lesions frequently harbour somatic gain-of-function mutations in MAP3K3 and PIK3CA. However, the mechanisms by which these somatic mutations drive lesion development remain incompletely...

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Identifiers

PMID: 41552909
DOI: 10.1093/brain/awag017

Genes

MAP3K3
PIK3CA

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

Related research

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Angiogenic switching in cerebral cavernous malformations driven by MAP3K3-PIK3CA synergy.PMID 41552909Read ↗

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Somatic variants of MAP3K3 are sufficient to cause cerebral and spinal cord cavernous malformations.Semantic proximity Read ↗

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