Article

Inhibition of METTL3 by STC-15 induces RNA misprocessing that results in dsRNA formation and activates innate immunity

2025-12-09

Abstract excerpt

<h4>Summary</h4> The RNA methyltransferase METTL3 is responsible for the generation of m6A, the most abundant modification mark on mRNA and long non-coding RNA. Accumulating evidence suggests numerous roles of METTL3 in cancer initiation and progression and highlights the potential for targeting this enzyme in oncology. STC-15 is a potent and selective METTL3 inhibitor and the first RNA modifying enzyme inhibitor...

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Literature Corpus work: 889ad849-a9cf-5c37-bfdf-ce6aa1ea5c6d
DOI: 10.64898/2025.12.05.692335

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