Article
Noninvasive detection of twin zygosity using genome-wide linkage disequilibrium information.
Clinical and translational medicine - 1 Dec 2024
Kong Lingrong, Yang Yingjun, Yuan Chao, Wei Xing, Zhou Xinyao, Zhou Jia, Xing Ya, Zou Gang, Sun Qianqian, Cai Luyao, Liang Qiufeng, Zhang Yao, Wang Hongkun, Liu Zesi, Wu Di, Sun Luming
Abstract excerpt
Dear Editor, in this study, we propose a novel linkage disequilibrium information-based noninvasive zygosity (LDNZ) assessment method in twin pregnancies. It combines fetus-specific allele frequency analysis with LD block to reduce the number of required single nucleotide polymorphism markers and experiment costs. LDNZ method offers a noninvasive, accurate, and cost-effective solution for zygosity assessment,...
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