Article

Inference of maternal allele inheritance via Bayesian hierarchical model in noninvasive prenatal diagnosis

2016-05-06

Abstract excerpt

Noninvasive prenatal diagnosis (NIPD) poses a promising solution for detecting genetic alterations in fetus genome. However, the inference of the maternal allele inheritance in monogenic autosomal recessive disease is still challenging. Here the Bayesian hierarchical model is proposed to deduce the allele inheritance basing on haplotype frequency. The Bayesian approach, which does not depend on the knowledge of fe...

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Literature Corpus work: 0bae4422-d3cd-5282-a175-afaecb1bbf3b
DOI: 10.1101/051995

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