Article
TwinEQTL: ultrafast and powerful association analysis for eQTL and GWAS in twin studies.
Genetics - 30 Jul 2022
Xia Kai, Shabalin Andrey A, Yin Zhaoyu, Chung Wonil, Sullivan Patrick F, Wright Fred A, Styner Martin, Gilmore John H, Santelli Rebecca C, Zou Fei
Abstract excerpt
We develop a computationally efficient alternative, TwinEQTL, to a linear mixed-effects model for twin genome-wide association study data. Instead of analyzing all twin samples together with linear mixed-effects model, TwinEQTL first splits twin samples into 2 independent groups on which multiple linear regression analysis can be validly performed separately, followed by an appropriate meta-analysis-like approach...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.