Skeletal Phenotyping of Period-1-Deficient Melatonin-Proficient Mice.

Abstract excerpt

In mice, variability in adult bone size and density has been observed among common inbred strains. Also, in the group of genes regulating circadian rhythmicity in mice, so called clock genes, changes in body size and skeletal parameters have been noted in knockout mice. Here, we studied the size and density of prominent bones of the axial and appendicular skeleton of clock gene Period-1-deficient (Per1-/-) mice...

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