Article
Intrinsic muscle clock is necessary for musculoskeletal health.
The Journal of physiology - 15 Dec 2015
Schroder Elizabeth A, Harfmann Brianna D, Zhang Xiping, Srikuea Ratchakrit, England Jonathan H, Hodge Brian A, Wen Yuan, Riley Lance A, Yu Qi, Christie Alexander, Smith Jeffrey D, Seward Tanya, Wolf Horrell Erin M, Mula Jyothi, Peterson Charlotte A, Butterfield Timothy A, Esser Karyn A
Abstract excerpt
KEY POINTS: The endogenous molecular clock in skeletal muscle is necessary for maintenance of phenotype and function. Loss of Bmal1 solely from adult skeletal muscle (iMSBmal1(-/-) ) results in reductions in specific tension, increased oxidative fibre type and increased muscle fibrosis with no change in feeding or activity. Disruption of the molecular clock in adult skeletal muscle is sufficient to induce changes...
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