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Article

Impact of clock gene Bmal1 deficiency on nutritionally induced obesity in mice.

Obesity (Silver Spring, Md.) - 1 Mar 2011

Hemmeryckx Bianca, Himmelreich Uwe, Hoylaerts Marc F, Lijnen Henri R

Abstract excerpt

To evaluate the hypothesis that the clock gene Bmal1 (brain and muscle arnt like protein-1) plays a role in the development of obesity, 5-week-old male Bmal1-deficient (Bmal1(-/-)) mice and wild-type littermates (Bmal1(+/+)) were kept on a high-fat diet (HFD) for 15 weeks. Despite an initial accelerated weight gain of Bmal1(-/-) mice, body weight and subcutaneous (SC) and gonadal (GON) adipose tissue mass were...

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Identifiers

PMID: 21030946
DOI: 10.1038/oby.2010.266

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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