Article

Modeling the Clockwork of Bone: A Narrative Review of Experimental Approaches to Circadian Rhythm in Bone Metabolism

2026-04-24

Abstract excerpt

Circadian rhythms are fundamental regulators of bone remodeling, orchestrating the co-ordinated actions of osteoblasts, osteocytes, and osteoclasts. Recent studies have high-lighted how core clock genes, such as Bmal1, Clock, Per1/2, and Cry1/2, exhibit rhythmic expression in bone tissue and modulate key markers of bone formation and resorption. Disruptions in circadian regulations, whether caused by environmental...

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Literature Corpus work: ad0e8cc9-1084-5414-9e2c-aa0e8dbc9ce9
DOI: 10.20944/preprints202604.1709.v1

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