Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mutations associated with reduced surotomycin susceptibility in Clostridium difficile and Enterococcus species.

Antimicrobial agents and chemotherapy - 1 Jul 2015

Adams Hannah M, Li Xiang, Mascio Carmela, Chesnel Laurent, Palmer Kelli L

Abstract excerpt

Clostridium difficile infection (CDI) is an urgent public health concern causing considerable clinical and economic burdens. CDI can be treated with antibiotics, but recurrence of the disease following successful treatment of the initial episode often occurs. Surotomycin is a rapidly bactericidal cyclic lipopeptide antibiotic that is in clinical trials for CDI treatment and that has demonstrated superiority over...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Clostridioides difficile
Share to Daptomycin

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Enterococcus

Share to Lipopeptides

Share to Peptides, Cyclic

Share to Prohibitins

Share to Restriction Mapping

Share to Vancomycin Resistance

Source

Open in PubMed Open full text

Identifiers

PMID: 25941217
DOI: 10.1128/AAC.00526-15
PMCID: PMC4468737

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations associated with reduced surotomycin susceptibility in Clostridium difficile and Enterococcus species.PMID 25941217Read ↗

In vitro activity of surotomycin against contemporary clinical isolates of toxigenic Clostridium difficile strains obtained in Spain.Semantic proximity Read ↗

Mode of Action and Bactericidal Properties of Surotomycin against Growing and Nongrowing Clostridium difficileSemantic proximity Read ↗

In vitro selection, via serial passage, of Clostridium difficile mutants with reduced susceptibility to fidaxomicin or vancomycin.Semantic proximity Read ↗

Characterization of a stable, metronidazole-resistant Clostridium difficile clinical isolate.Semantic proximity Read ↗

Genetic determinants of resistance to antimicrobial therapeutics are rare in publicly available Clostridioides difficile genome sequences.Semantic proximity Read ↗

The use of high-throughput sequencing to investigate an outbreak of glycopeptide-resistant Enterococcus faecium with a novel quinupristin-dalfopristin resistance mechanism.Semantic proximity Read ↗

Multiple evolutionary pathways lead to vancomycin resistance in <i>Clostridioides difficile</i>Semantic proximity Read ↗

High-Throughput Analysis of Gene Essentiality and Sporulation in Clostridium difficileSemantic proximity Read ↗

Constitutive expression of the cryptic vanGCd operon promotes vancomycin resistance in Clostridioides difficile clinical isolatesSemantic proximity Read ↗

Genetic Basis for Daptomycin Resistance in EnterococciSemantic proximity Read ↗

Spectrum of activity and mode of action of REP3123, a new antibiotic to treat Clostridium difficile infectionsSemantic proximity Read ↗

Whole-genome analysis reveals the evolution and transmission of an MDR DH/NAP11/106 Clostridium difficile clone in a paediatric hospital.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.