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The effects of the interaction of genetic predisposition with lifestyle factors on bladder cancer risk.

BJU international - 1 Apr 2023

Yu Evan Yi-Wen, Liu Yu-Xiang, Chen Ya-Ting, Tang Qiu-Yi, Mehrkanoon Siamak, Wang Shi-Zhi, Li Wen-Chao, Zeegers Maurice P, Wesselius Anke

Abstract excerpt

OBJECTIVES: To investigate the association of polygenic risk score (PRS) and bladder cancer (BC) risk and whether this PRS can be offset by a healthy lifestyle. METHODS: Individuals with BC (n = 563) and non-BC controls (n = 483 957) were identified in the UK Biobank, and adjusted Cox regression models were used. A PRS was constructed based on 34 genetic variants associated with BC development, while a healthy...

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Cohort Studies
Genetic Predisposition to Disease
Life Style
Risk Factors
Urinary Bladder Neoplasms

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PMID: 36053730
DOI: 10.1111/bju.15880

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