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Article

GLP-1R Gene Polymorphisms and Metabolic Traits During Childhood and Adolescence: The EPOCH Study.

The Journal of clinical endocrinology and metabolism - 7 Aug 2025

Harrall Kylie K, Glueck Deborah H, Lange Leslie A, Litkowski Elizabeth M, Vanderlinden Lauren A, Konigsberg Iain R, Cree Melanie G, Perng Wei, Dabelea Dana

Abstract excerpt

CONTEXT: This is the first study to examine the association between variants of the glucagon-like-peptide-1 receptor gene (GLP-1R) and metabolic characteristics among youth. OBJECTIVE: We explored separate associations of 3 GLP-1R polymorphisms (rs10305420, rs6923761, and rs1042044) with body mass index (BMI) trajectories and markers of glucose-insulin homeostasis. METHODS: Mixed models examined associations...

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Identifiers

PMID: 39693247
DOI: 10.1210/clinem/dgae880
PMCID: PMC13339249

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