Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Novel epigenetic marks of insulin resistance trajectories in a longitudinal study of childhood obesity.

Cardiovascular diabetology - 24 Feb 2026

Anguita-Ruiz Augusto, Torres-Martos Álvaro, Bustos-Aibar Mireia, Setó-Llorens Adrià, Ruiz-Ojeda Francisco Javier, Moreno Luis A, Gil Ángel, Gil-Campos Mercedes, Bueno Gloria, Leis Rosaura, Alcalá-Fdez Jesús, Aguilera Concepción M

Abstract excerpt

BACKGROUND: Childhood obesity is a major global public-health challenge. Insulin resistance (IR) is a critical driver of later cardiometabolic alterations. A comprehensive understanding of the molecular mechanisms underlying the initial development of childhood IR is essential for timely prevention and intervention. In this study, we aimed to assess the association between IR and blood DNA methylation in a...

Topics

Join the communities discussing this publication.

Adiposity
Blood Glucose
CpG Islands
Insulin
Insulin Resistance

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Longitudinal Studies

Pediatric Obesity

Source

Open in PubMed Open full text

Identifiers

PMID: 41736036
DOI: 10.1186/s12933-026-03101-7
PMCID: PMC13041278

Genes

SLC2A9
TSC2
EGLN3
EHD2
PEPD
VASN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Novel epigenetic marks of insulin resistance trajectories in a longitudinal study of childhood obesity.PMID 41736036Read ↗

DNA methylation and body mass index from birth to adolescence: meta-analyses of epigenome-wide association studiesSemantic proximity Read ↗

Vasorin as a multi-omic biomarker of cardiometabolic health in paediatric obesitySemantic proximity Read ↗

Pre-adolescence DNA methylation is associated with BMI status change from pre- to post-adolescence.Semantic proximity Read ↗

Maternal obesity and gestational diabetes reprogram the methylome of offspring beyond birth by inducing epigenetic signatures in metabolic and developmental pathwaysSemantic proximity Read ↗

Trans-ancestry genome-wide association study of childhood body mass index identifies novel loci and age-specific effects.Semantic proximity Read ↗

DNA methylation marks associated with body composition in children from India and the Gambia - findings from the EMPHASIS studySemantic proximity Read ↗

Maternal BMI as a predictor of methylation of obesity-related genes in saliva samples from preschool-age Hispanic children at-risk for obesity.Semantic proximity Read ↗

Childhood DNA methylation as a marker of early life rapid weight gain and subsequent overweight.Semantic proximity Read ↗

An overview about DNA methylation in childhood obesity: Characteristics of the studies and main findings.Semantic proximity Read ↗

Insulin-Like Growth Factor 2/H19 Methylation at Birth and Risk of Overweight and Obesity in ChildrenSemantic proximity Read ↗

A trans-ancestral meta-analysis of genome-wide association studies reveals loci associated with childhood obesity.Semantic proximity Read ↗

DNA methylation profiles in the blood of newborn term infants born to mothers with obesitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.