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Article

T cells from patients with Parkinson's disease recognize α-synuclein peptides.

Nature - 29 Jun 2017

Sulzer David, Alcalay Roy N, Garretti Francesca, Cote Lucien, Kanter Ellen, Agin-Liebes Julian, Liong Christopher, McMurtrey Curtis, Hildebrand William H, Mao Xiaobo, Dawson Valina L, Dawson Ted M, Oseroff Carla, Pham John, Sidney John, Dillon Myles B, Carpenter Chelsea, Weiskopf Daniela, Phillips Elizabeth, Mallal Simon, Peters Bjoern, Frazier April, Lindestam Arlehamn Cecilia S, Sette Alessandro

Abstract excerpt

Genetic studies have shown the association of Parkinson's disease with alleles of the major histocompatibility complex. Here we show that a defined set of peptides that are derived from α-synuclein, a protein aggregated in Parkinson's disease, act as antigenic epitopes displayed by these alleles and drive helper and cytotoxic T cell responses in patients with Parkinson's disease. These responses may explain the...

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Source

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Identifiers

PMID: 28636593
DOI: 10.1038/nature22815
PMCID: PMC5626019

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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