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Article

Towards Understanding the Catalytic Mechanism of Human Paraoxonase 1: Experimental and In Silico Mutagenesis Studies.

Applied biochemistry and biotechnology - 1 Aug 2017

Tripathy Rajan K, Aggarwal Geetika, Bajaj Priyanka, Kathuria Deepika, Bharatam Prasad V, Pande Abhay H

Abstract excerpt

Human paraoxonase 1 (h-PON1) is a ~45-kDa serum enzyme that can hydrolyze a variety of substrates, including organophosphate (OP) compounds. It is a potential candidate for the development of antidote against OP poisoning in humans. However, insufficient OP-hydrolyzing activity of native enzyme affirms the urgent need to develop improved variant(s) having enhanced OP-hydrolyzing activity. The crystal structure of...

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Source

Identifiers

PMID: 28161867
DOI: 10.1007/s12010-017-2424-5

Genes

PON1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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