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Identification of TCR repertoires in functionally competent cytotoxic T cells cross-reactive to SARS-CoV-2

2 Dec 2021

Abstract excerpt

Abstract SARS-CoV-2-specific CD8 + T cells are scarce but detectable in unexposed healthy donors (UHDs). It remains unclear whether pre-existing human coronavirus (HCoV)-specific CD8 + T cells are converted to functionally competent T cells cross-reactive to SARS-CoV-2. Here, we identified the HLA-A24-high binding, immunodominant epitopes in SARS-CoV-2 spike region that can be recognized by seasonal...

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PMID: 34857854
DOI: 10.1038/s42003-021-02885-6

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