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Structural insights into protection against a SARS-CoV-2 spike variant by T cell receptor diversity

16 Feb 2023

Abstract excerpt

T cells play a crucial role in combatting SARS-CoV-2 and forming long-term memory responses to this coronavirus. The emergence of SARS-CoV-2 variants that can evade T cell immunity has raised concerns about vaccine efficacy and the risk of reinfection. Some SARS-CoV-2 T cell epitopes elicit clonally restricted CD8 + T cell responses characterized by T cell receptors (TCRs) that lack structural diversity....

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PMID: 36806685
DOI: 10.1016/j.jbc.2023.103035

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