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Molecular Basis of a Dominant SARS-CoV-2 Spike-Derived Epitope Presented by HLA-A*02:01 Recognised by a Public TCR.

Cells - 3 Oct 2021

Szeto Christopher, Nguyen Andrea T, Lobos Christian A, Chatzileontiadou Demetra S M, Jayasinghe Dhilshan, Grant Emma J, Riboldi-Tunnicliffe Alan, Smith Corey, Gras Stephanie

Abstract excerpt

The data currently available on how the immune system recognises the SARS-CoV-2 virus is growing rapidly. While there are structures of some SARS-CoV-2 proteins in complex with antibodies, which helps us understand how the immune system is able to recognise this new virus; however, we lack data on how T cells are able to recognise this virus. T cells, especially the cytotoxic CD8+ T cells, are critical for viral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HLA-A2 Antigen

Share to Protein Denaturation

Share to Receptors, Antigen, T-Cell

Share to Spike Glycoprotein, Coronavirus

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Share to T-Lymphocytes, Cytotoxic

Source

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Identifiers

PMID: 34685626
DOI: 10.3390/cells10102646
PMCID: PMC8534114

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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