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Macrophage-Derived Type 1 IFN, Renal Tubular Epithelial Cell Polyploidization, and AKI-to-CKD Transition

11 Dec 2024

Abstract excerpt

Key Points Macrophage-derived IFN- β contributes to tubular epithelial cell polyploidization after AKI. IFN- β induced tubular epithelial cell polyploidization by regulating inorganic pyrophosphatase-mediated yes-associated protein (YAP) dephosphorylation. Delayed blockade of the IFN- β response attenuated persistent polyploidization and kidney fibrosis. Background AKI is recognized as a common risk factor of...

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PMID: 39665291
DOI: 10.1681/asn.0000000577

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