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Tubular cell polyploidy protects from lethal acute kidney injury but promotes consequent chronic kidney disease

4 Oct 2022

Abstract excerpt

Acute kidney injury (AKI) is frequent, often fatal and, for lack of specific therapies, can leave survivors with chronic kidney disease (CKD). We characterize the distribution of tubular cells (TC) undergoing polyploidy along AKI by DNA content analysis and single cell RNA-sequencing. Furthermore, we study the functional roles of polyploidization using transgenic models and drug interventions. We identify...

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PMID: 36195583
DOI: 10.1038/s41467-022-33110-5

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