Article
Unravelling the genetic architecture of cerebral small vessel disease in the context of stroke.
Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism - 1 Jun 2026
Chakkarai Sathyaseelan, Le Grand Quentin, Shaoxuan Lucas Wang, Debette Stephanie, Sargurupremraj Muralidharan
Abstract excerpt
Cerebral small vessel disease (cSVD) is a major contributor to stroke, dementia, and cognitive decline. Despite significant progress through large-scale genome-wide association studies (GWAS) for cSVD and stroke, the genetic architecture underlying these conditions remains poorly understood. This review highlights recent advancements in statistical tools and provides a comprehensive overview of current insights...
Topics
- Cerebral Small Vessel Diseases
- Humans
- Stroke
- Genome-Wide Association Study
- Genetic Predisposition to Disease
- Polymorphism, Single Nucleotide