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SURFBAT: a surrogate family based association test building on large imputation reference panels.

G3 (Bethesda, Md.) - 17 Apr 2025

Herzig Anthony F, Rubinacci Simone, Marenne Gaëlle, Perdry Hervé, Deleuze Jean-François, Dina Christian, Barc Julien, Redon Richard, Delaneau Olivier, Génin Emmanuelle

Abstract excerpt

Genotype-phenotype association tests are typically adjusted for population stratification using principal components that are estimated genome-wide. This lacks resolution when analyzing populations with fine structure and/or individuals with fine levels of admixture. This can affect power and precision, and is a particularly relevant consideration when control individuals are recruited using geographic selection...

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PMID: 39657733
DOI: 10.1093/g3journal/jkae287
PMCID: PMC12005154

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