PIK3CA Mutation in HPV-Associated OPSCC Patients Receiving Deintensified Chemoradiation.

doi:10.1093/jnci/djz224

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Article

PIK3CA Mutation in HPV-Associated OPSCC Patients Receiving Deintensified Chemoradiation.

Journal of the National Cancer Institute - 1 Aug 2020

Beaty Brian T, Moon Dominic H, Shen Colette J, Amdur Robert J, Weiss Jared, Grilley-Olson Juneko, Patel Shetal, Zanation Adam, Hackman Trevor G, Thorp Brian, Blumberg Jeffrey M, Patel Samip N, Weissler Mark C, Yarbrough Wendell G, Sheets Nathan C, Parker Joel S, Neil Hayes D, Weck Karen E, Ramkissoon Lori A, Mendenhall William M, Dagan Roi, Tan Xianming, Gupta Gaorav P, Chera Bhishamjit S

Abstract excerpt

PIK3CA is the most frequently mutated gene in human papillomavirus (HPV)-associated oropharyngeal squamous cell carcinoma (OPSCC). Prognostic implications of such mutations remain unknown. We sought to elucidate the clinical significance of PIK3CA mutations in HPV-associated OPSCC patients treated with definitive chemoradiation (CRT). Seventy-seven patients with HPV-associated OPSCC were enrolled on two phase II...

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PMID: 31747025
DOI: 10.1093/jnci/djz224

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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