Article

Elective Node Sparing in Head-and-Neck Cancer Radiotherapy Reduces Lymphocyte Damage, Lymphopenia, and Modulates Immune Signatures

2026-05-25

Abstract excerpt

<h4>Purpose</h4> Elective nodal (EN) irradiation (ENI) during radiotherapy for locally advanced head-and-neck squamous cell carcinoma (LA-HNSCC) influences hematotoxicity, anti-tumor immunity, and synergy with immunotherapy. We evaluated whether EN-sparing upfront boosts affect DNA damage, systemic immune signaling in peripheral blood lymphocytes (PBLs), and radiation-induced lymphopenia (RIL). <h4>Methods and Ma...

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Literature Corpus work: dae91362-64e7-58ab-ad4b-bf1324b5c42e
DOI: 10.64898/2026.05.20.26352898

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