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Article

Role of BRCA1 in glioblastoma etiology.

Cellular oncology (Dordrecht, Netherlands) - 1 Dec 2024

Harbi Emirhan, Aschner Michael

Abstract excerpt

BRCA1 (Breast Cancer 1) is a tumor suppressor gene with a role in DNA repair by Homologous Recombination (HR), and maintenance of genomic stability that is frequently investigated in breast, prostate, and ovarian cancers. BRCA1 mutations or dysregulation in glioblastoma can lead to impaired DNA repair mechanisms, resulting in tumor progression and resistance to standard therapies. Several studies have shown that...

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Source

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Identifiers

PMID: 39656422
DOI: 10.1007/s13402-024-01024-7
PMCID: PMC12974051

Genes

BRCA1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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