Article
Quantitative perturbation-phenotype maps reveal nonlinear responses underlying robustness of PAR-dependent asymmetric cell division.
PLoS biology - 1 Dec 2024
Rodrigues Nelio T L, Bland Tom, Ng KangBo, Hirani Nisha, Goehring Nathan W
Abstract excerpt
A key challenge in the development of an organism is to maintain robust phenotypic outcomes in the face of perturbation. Yet, it is often unclear how such robust outcomes are encoded by developmental networks. Here, we use the Caenorhabditis elegans zygote as a model to understand sources of developmental robustness during PAR polarity-dependent asymmetric cell division. By quantitatively linking alterations in...
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