Article
Developmental nonlinearity drives phenotypic robustness.
Nature communications - 6 Dec 2017
Green Rebecca M, Fish Jennifer L, Young Nathan M, Smith Francis J, Roberts Benjamin, Dolan Katie, Choi Irene, Leach Courtney L, Gordon Paul, Cheverud James M, Roseman Charles C, Williams Trevor J, Marcucio Ralph S, Hallgrímsson Benedikt
Abstract excerpt
Robustness to perturbation is a fundamental feature of complex organisms. Mutations are the raw material for evolution, yet robustness to their effects is required for species survival. The mechanisms that produce robustness are poorly understood. Nonlinearities are a ubiquitous feature of development that may link variation in development to phenotypic robustness. Here, we manipulate the gene dosage of a...
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