Article
The measles virus matrix F50S mutation from a lethal case of subacute sclerosing panencephalitis promotes receptor-independent neuronal spread.
Journal of virology - 31 Jan 2025
Yousaf Iris, Domanico Luke, Nambara Toshihiko, Yadav Kalpana, Kelly Lauren K, Trejo-Lopez Jorge, Shieh Wun-Ju, Rota Paul A, Devaux Patricia, Kanekiyo Takahisa, Taylor Matthew P, Cattaneo Roberto
Abstract excerpt
Subacute sclerosing panencephalitis (SSPE) is a lethal neurological disorder occurring several years after measles. Reconstruction of the evolution of the measles virus (MeV) genome in an SSPE case suggested that the matrix (M) protein mutation M-F50S, when added to other mutations, drove neuropathogenesis. However, whether and how M-F50S would promote spread independently from other mutations was in question. We...
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