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Article

Fitness selection of hyperfusogenic measles virus F proteins associated with neuropathogenic phenotypes.

Proceedings of the National Academy of Sciences of the United States of America - 4 May 2021

Ikegame Satoshi, Hashiguchi Takao, Hung Chuan-Tien, Dobrindt Kristina, Brennand Kristen J, Takeda Makoto, Lee Benhur

Abstract excerpt

Measles virus (MeV) is resurgent and caused >200,000 deaths in 2019. MeV infection can establish a chronic latent infection of the brain that can recrudesce months to years after recovery from the primary infection. Recrudescent MeV leads to fatal subacute sclerosing panencephalitis (SSPE) or measles inclusion body encephalitis (MIBE) as the virus spreads across multiple brain regions. Most clinical isolates of...

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Identifiers

PMID: 33903248
DOI: 10.1073/pnas.2026027118
PMCID: PMC8106313

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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