Article
Generation and properties of measles virus mutations typically associated with subacute sclerosing panencephalitis.
Annals of the New York Academy of Sciences - 6 Jun 1994
Billeter M A, Cattaneo R, Spielhofer P, Kaelin K, Huber M, Schmid A, Baczko K, ter Meulen V
Abstract excerpt
Subacute sclerosing panencephalitis (SSPE), a very rare but lethal disease caused by measles viruses (MV) persisting in the human central nervous system (CNS) is characterized by lack of viral budding, reduced expression of the viral envelope proteins and spread of MV genomes through the CNS despite massive immune responses. The five major MV genes from several SSPE cases were cloned and sequenced, the two...
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- Amino Acid Sequence
- Animals
- Humans
- Measles virus
- Molecular Sequence Data
- Mutation