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Article

The interplay between cytokines and stroke: a bi-directional Mendelian randomization study.

Scientific reports - 26 Jul 2024

Jiang Yingying, Liu Qingying, Wang Chunyang, Zhao Yumei, Jin Chen, Sun Ming, Ge Siqi

Abstract excerpt

Stroke, the second leading cause of death and disability, causes massive cell death in the brain followed by secondary inflammatory injury initiated by disease associated molecular patterns released from dead cells. Nonetheless, the evidence regarding the causal relationship between inflammatory cytokines and stroke subtypes is obscure. To leverage large scale genetic association data to investigate the interplay...

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Cytokines
Genetic Predisposition to Disease
Genome-Wide Association Study
Ischemic Stroke
Mendelian Randomization Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymorphism, Single Nucleotide

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Identifiers

PMID: 39085243
DOI: 10.1038/s41598-024-67615-4
PMCID: PMC11291972

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