COMT Val158Met polymorphism protects the impact of a mother's history of childhood trauma on emotional and behavioural problems in preschool children.

doi:10.1111/ejn.16631

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

COMT Val158Met polymorphism protects the impact of a mother's history of childhood trauma on emotional and behavioural problems in preschool children.

The European journal of neuroscience - 1 Dec 2024

Xavier Janaína, Bastos Clarissa Ribeiro, Marins Thayane Moreira, Camerini Laísa, Behling De Mello Daniele, Antunes Bruna, de Ávila Quevedo Luciana, de Matos Mariana Bonati, Pinheiro Ricardo Tavares, Ghisleni Gabriele

Abstract excerpt

Childhood trauma has a well-established negative impact on mental health outcomes across the lifespan. Cumulative evidence suggests an intergenerational transmission of trauma to descendants. In this way, considering the child's COMT Val158Met (rs4680: G > A) variant, the study aims to investigate the interactive effect of maternal childhood trauma on the emotional/behavioural problems of their offspring in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adverse Childhood Experiences

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Affective Symptoms

Share to Catechol O-Methyltransferase

Share to Child

Share to Child Behavior Disorders

Share to Child, Preschool

Share to Mothers

Share to Pregnancy

Source

Open in PubMed

Identifiers

PMID: 39631778
DOI: 10.1111/ejn.16631

Genes

COMT

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

COMT Val158Met polymorphism protects the impact of a mother's history of childhood trauma on emotional and behavioural problems in preschool children.PMID 39631778Read ↗

Interaction between COMT Val158 Met polymorphism and childhood trauma predicts risk for depression in men.Semantic proximity Read ↗

Effects of childhood trauma experience and COMT Val158Met polymorphism on brain connectivity in a multimodal MRI study.Semantic proximity Read ↗

Relationship between the COMT-Val158Met and BDNF-Val66Met polymorphisms, childhood trauma and psychotic experiences in an adolescent general population sample.Semantic proximity Read ↗

Interplay between COMT Val158Met, childhood adversities and sex in predicting panic pathology: Findings from a general population sample.Semantic proximity Read ↗

The interaction of early life experiences with COMT val158met affects anxiety sensitivity.Semantic proximity Read ↗

Emotional symptoms in children: The effect of maternal depression, life events, and COMT genotype.Semantic proximity Read ↗

Interactions Between Early Trauma and Catechol-O-Methyltransferase Genes on Inhibitory Deficits in Children With ADHD.Semantic proximity Read ↗

The divergent impact of catechol-O-methyltransferase (COMT) Val158Met genetic polymorphisms on executive function in adolescents with discrete patterns of childhood adversity.Semantic proximity Read ↗

Gene-Environment Correlation Across Trauma Subtypes and Developmental Timing: Evidence From the EU-GEI and ALSPAC.Semantic proximity Read ↗

The catechol-O-methyltransferase (COMT) Val158Met polymorphism moderates the effect of antenatal stress on childhood behavioural problems: longitudinal evidence across multiple ages.Semantic proximity Read ↗

Early life adversity and cardiovascular responses to repeated stress among adolescents: Moderating role of COMT gene rs4680 polymorphism.Semantic proximity Read ↗

Genetic pathways to posttraumatic stress disorder and depression in children: Investigation of catechol-O-methyltransferase (COMT) Val158Met using different PTSD diagnostic models.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.